羟吡酮 | 68890-66-4_Q_化工词典

中文同义词:去屑剂;吡罗克酮乙醇铵;1-羟基-4-甲基-6-(2,4,4-三甲苯基)吡啶酮乙醇胺复合盐;吡罗克酮乙醇胺盐;吡啶酮乙醇胺盐(去屑剂OCTO);吡啶酮乙醇胺盐;羟吡酮;罗酮奥拉明

英文同义词:2(1H)-Pyridinone,1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-,compd.with2-aminoethanol(1:1);4,4-trimethylpentyl)-1-hydroxy-4-methyl-6-(compd.with2-2(1h)-pyridinon;octopiroxolamine;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1h)-pyridinoncompd.with2-aminoethanol(1:1);Hydroxylpyrazoleketones;1-Hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridonmonoethanolamine;1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl);-onecompoundwith2-aminoethanol(1:1)

EINECS号:272-574-2

羟吡酮性质

熔点 134.0 to 138.0 °C

储存条件 2-8°C

形态neat

InChIKey BTSZTGGZJQFALU-UHFFFAOYSA-N

生物活性

Piroctone olamine 是一种吡啶衍生物。具有杀真菌作用。

靶点

Antifungal

体外研究

Piroctone olamine, the ethanolamine salt of the hydroxamic acid derivative Piroctone, is a hydroxypyridone anti-mycotic agent. Piroctone olamine penetrates the cell membrane and forms complexes with iron ions, inhibiting energy metabolism in mitochondria. Piroctone olamine (PO) is an ethanolamine salt of the hydroxamic acid derivative Piroctone. All Candida strains show low minimum inhibitory concentrations (MICs) for Piroctone olamine (0.125-0.5 μg/mL) and Amphotericin B (AMB) (0.03-1 μg/mL).

体内研究

This work aimed to evaluate the antifungal activity of Piroctone olamine in the treatment of intra-abdominal candidiasis in an experimental model using Swiss mice. The treatment with Piroctone olamine (0.5 mg/kg) is performed 72 h after infection by intraperitoneal administration. For comparison, a group of animals (n=6) is treated with Amphotericin B (0.5 mg/kg). The mycological diagnosis is made by collecting the liver, spleen and kidneys. Data regarding the fungal growth and mortality are analyzed statistically by Student’s t test and analysis of variance, with level of significance set at P<0.05. The difference in fungal growth scoring between the control group and the treatment groups (Piroctone olamine and Amphotericin B) is statistically significant (P<0.05).